Review Article

Nov - December 2018  |  Vol: 4  |  Issue: 6
A Review on Buccal Film: A Modern Expansion in Drug Delivery System

Madhuri B. Narode, Kajal L. Sonawane, Roshani B. Khairnar, Purva P. Dusad, Dr. Shailesh S. Chalikwar*

Department of Pharmaceutical Quality Assurance

R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dist. Dhule (MS) India 425405

 

Address for Correspondence: -

Dr. Shailesh S. Chalikwar

Professor and Head,

Department of Pharmaceutical Quality Assurance,

R. C. Patel Institute of Pharmaceutical Education

and Research, Shirpur, Dist: Dhule (M.S.) India 425 405

Mobile – 91 – 9850104541 and 91 - 9175557871

Email: pharmashailesh@rediffmail.com

 

 

Abstract

Objective: Main objective is to develop and characterize buccal films for low bioavailability drugs, which are suffering from presystemic metabolism. Now a day’s extensive research is being carried out to improve efficacy, safety and patient compliance, for this there is a further need to design and develop advanced drug delivery systems. Development of buccal film is one of the challenges in the advanced drug delivery system. Buccal route is the best site for local as well as systemic administration of drugs, due to the physiological nature of buccal mucosa.

Method: Several methods such as solvent casting, hot melt extrusion, solid dispersion extrusion, rolling, spray technique and semi-solid casting methods are utilized to develop buccal films. All characterization parameters are discussed here with detailed procedure.

Result: This method serves as a best alternative. It has numerous advantages than other traditional types of drug delivery systems. Literature survey reveals that pulmonary, ocular, nasal, rectal, buccal, sublingual, vaginal, and transdermal routes are options for administration of drug having poor oral availability and extensive first pass metabolism but use of such alternative routes/drug delivery systems has limited success because of their inherent drawbacks.

Conclusion: Buccal films are suitable for delivery of low bioavailable drugs, which are suffering from first pass metabolism. Present review is focus on advantages, disadvantages, ideal characteristics for drug and excipients, compositions, formulation methods and evaluation parameters of buccal film.

Keywords: Orodispersible buccal films, Mucoadhesive buccal films, Drug selection for buccal films, Composition, Formulation methods, Evaluation Parameters.

 

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