Review Article

Sep - October 2018  |  Vol: 4  |  Issue: 5
Transferosome: A Nobel Approach for Transdermal Drug Delivery System

Pallav Namdeo, Ashish Garg*, Sweta Garg

Department of P.G. Studies and Research in Chemistry and Pharmacy, Rani Durgavati University, Jabalpur, 482001, M.P.

 

*Address for Corresponding Author:

Ashish Garg

Department of P.G. Studies and Research

 in Chemistry and Pharmacy,

Rani Durgavati University,

Jabalpur, 482001, M.P.

Email: ashish.garg071010@gmail.com

 

Abstract        

Objective: Transdermal drug delivery appears to be the most vital drug delivery system because of its merit over conventional systems. Material and Method: Various strategies can be used to augment the transdermal delivery which includes iontophoresis, electrophoresis, sonophoresis, chemical permeation enhancers, microneedles, and vesicular system (Liposomes, Niosomes, Elastic Liposomes such as Ethosomes and Transfersomes). The transfersomal system was much more efficient among all these strategies. These can deform and pass through narrow constriction (from 5 to 10 times less than their own diameter) without measurable loss. The system can be characterized by in vitro for vesicle shape and size, entrapment efficiency, degree of deformability, number of vesicles per cubic mm. The deformability characteristic of transfersomes gives better permeation of drugs. With oral and parenteral drug delivery systems, or patient compliance is a frequent problem observed in daily clinical practice. Transport of drug across the skin is best route of drug delivery, because the skin is largest human organ with total weight 3 kg and a surface of 1.5-2.0 m2. But the big hurdle in transdermal delivery of drug is the skin, the stratum corneum, the outermost envelop of the skin. Conclusion: Recently, various strategies have been used to augment to the transdermal delivery. Mainly, they include iontophoresis, electrophoresis, sonophoresis, chemical permeation enhancers, microneedles, and vesicular system (liposomes, niosomes, elastic liposomes such as ethosomes and transfersomes). Transfersomes possess an infrastructure consists of hydrophobic and hydrophilic moieties together and as a result can accommodate drug molecules with wide range of solubility. Transfersomes can deform and pass through narrow constriction (from 5 to 10 times less than their own diameter) without measurable loss. Transfersomes penetrate through the pores of stratum corneum which are smaller than its size and get into the underlying viable skin in intact form due to its deformable nature. The system can be characterized by in vitro for vesicle shape and size, entrapment efficiency, degree of deformability, number of vesicles per cubic mm. This high deformability gives better penetration of intact vesicles. They can act as a carrier for low as well as high molecular weight drugs e.g. analgesic, anesthetic, corticosteroids, sex hormones, anticancer, insulin, gap junction protein, and albumin. The present review highlights the formulation aspects, characterization, and therapeutic applications of transfersomes.

Keywords: includes iontophoresis, electrophoresis, sonophoresis, chemical permeation enhancers, microneedles, and vesicular system.

 

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