Ajay Kumar Shukla, Manish Kumar, Ram Singh Bishnoi, Vijay Singh Kachawa, C.P. Jain
Department of Pharmaceutical Science, Mohanlal Sukhadia University Udaipur Rajasthan, India
* Corresponding author,
Ajay Kumar Shukla
Department of Pharmaceutical Science,
Mohanlal Sukhadia University
Udaipur Rajasthan, India
Aim: In Oral drug delivery is the most prefer and convenient option as the oral route provides most active surface area among all drug delivery system for administration of different drugs. Frequently conventional dosage form produces extensive range of fluctuation in drug concentration in the bloodstream and tissues with consequent unwanted toxicity and poor efficiency. The maintenance of concentration of drug molecules in blood plasma within therapeutic index is very critical for efficient treatment. These factors as well as factors such as repetitive dosing and unpredictable absorption direct to the concept of oral sustained release dosage formulations. Methodology: Various reports were taken from review or research articles and other online available literature. Conclusion: In this review articles covers all the biopharmaceutical and physiochemical factors of formulation and development of sustained release dosage forms, which gives idea for selection of drug molecules to develop of sustained release dosage formulation successfully.
Keywords: Sustained release drug delivery system, Controlled release drug delivery system, Biopharmaceutics.