Review Article

Nov - December 2018  |  Vol: 4  |  Issue: 6
Genotoxicity of Drugs: Introduction, Prediction and Evaluation

Sagar Kishor Savale *

*Department of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and Research Shirpur, Dist. Dhule, Maharashtra, India.

 

*Corresponding Author,

Mr. Sagar Kishor Savale,

Department of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and Research Shirpur,

Dist. Dhule, Maharashtra, India.

Email: avengersagar16@gmail.com

Mob. No. 9960885333.

 

 

ABSTRACT

Genotoxicity is a word in genetics defined as a destructive effect on a cell's genetic material (DNA, RNA) affecting its integrity. Genotoxins are mutagens; they can cause mutations. Genotoxins include both radiation and chemical genotoxins. A substance that has the property of genotoxicity is known as a genotoxin. There are three primary effects that genotoxins can have on organisms by affecting their genetic information. Genotoxins can be carcinogens, or cancer-causing agents, mutagens, or mutation-causing agents, or teratogens, birth defect-causing agents. In most cases, genotoxicity leads to mutations in various cells and other bodily systems. Mutations can lead to a host of other problems, from cancer to a wide variety of different diseases. Mutations can come in many different forms; genetic information can be duplicated, deleted, or inserted. The present review focus on need of genotoxicity, importance of genotoxicity, Mechanisam of genotoxicity, genotoxicity testing, prediction (in silico software) and Evaluation of genotoxicity.

KEY WORDS:Genotoxicity, Genotoxins, mutagens, Ames test, in silico Software, carcinogens.

 

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