Satya Prakash Chand Kaushik*1, Kush B1, Manish Kumar2, Ajay Kumar Shukla*2, Suresh Kumar Dev2
1Dept. of pharmaceutics, Jaipur College of Pharmacy, Jaipur, Rajasthan, India.
2Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan, India
* Corresponding author,
Mr. Ajay Kumar Shukla
Department of Pharmaceutical Sciences,
Mohanlal Sukhadia University,
Udaipur, Rajasthan, India
The aim of this study was to formulate and characterization of dispersible tablet (Aceclofenac). Aceclofenac is a phenylacetic acid belongs to the group of non-steroidal anti-inflammatory drug (NSAID). It causes by inhibition of COX-2 and prostaglandin E2(PGE2) synthesis in blood mononuclear and polymorphonuclear cells.It used as anti-rheumatic, anti-inflammatory (both acute and chronic),analgesic (effective pain killer in lower backache, dental or gynecological pain) and antipyretic. In present study, disintegrants(crospovidone and sodium starch glycolate) with are used. Evaluation of different batches of tablets by thickness, weigh variation, hardness, friability, drug content uniformity, wetting time, water absorption ratio, in-vitro disintegration time and in-vitro drug release. Quantitative analyzes of aceclofenac by UV-Spectrophotometry, High Performance Liqud Chromatography (HPLC) and Mass Spectroscopy. Three formulation patterns were used for in-vitro drug release study.
Keywords-Aceclofenac, crospovidone, sodium starch glycolate, in-vitro disintegration time