*Sagar Kishor Savale
*Department of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, MS, India
*Author for correspondence:
Mr. Sagar Kishor Savale,
Department of Pharmaceutics,
R. C. Patel Institute of Pharmaceutical
Education & Research, Karwand Naka,
Shirpur, 425405, Dist. Dhule,
Maharashtra State, India.
Mobile No: +91 9960885333.
Email ID: firstname.lastname@example.org
Objective: Quercetin-flavonoid-polyphenolic has gained attention in prevention of brain cancer. The low permeability of Quercetin (QUR) across the blood-brain-barrier (BBB) leads to its insufficient delivery which in turns result in low therapeutic index. Therefore, developing a novel approaches enhancing the CNS delivery of QUR are required for the treatment of Cancer. The aim of this research work was to develop in Nanoemulsion (NE) loaded with QUR, for CNS targeting. Method: Quercetin is a poorly water soluble anticancer drug, with oral bioavailability is about 4%. Nanoemulsion were fabricated by Spontaneous Emulsification technique. Oleic acid was used as oil. Tween 80 was employed as surfactant and Polyethylene glycol 400 was employed as co-surfactant. Conclusion: QUR loaded NE for intranasal delivery are considered as promising vehicle for its targeting to CNS to treat the brain cancer.
Keywords: Intranasal delivery, Nanoemulsion, Brain targeting, Spontaneous emulsification technique.